NEWS: Genagon Therapeutics has on Feb 4th entered into a worldwide commercial platform license agreement with Ligand Pharmaceticals inc.

Targeting novel signaling pathways

Genagon Therapeutics drug development is based on ground-breaking discoveries in inflammatory signaling active on tumor infiltrating leukocytes. Our therapeutics target these previously unstudied pathways of immune cell suppression which are induced by tumors as they evade the immune system.

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Cellport - discovering novel pathways

Genagon Therapeutics has developed an in-house platform, Cellport, for identifying novel pathways active on immune cells present in the tumor micro environment. Using the Cellport platform, Genagon Therapeutics discovered new pathways for inhibition of innate immunity by cancer cells. Active innate immune cells are essential in order to recruit and stimulate cancer specific T-cells to eliminate their target cells. Our biologics drug development programs aim to target these previously unstudied pathways in tumor infiltrating leukocytes. The program opens new opportunities for novel combination therapies with current T-cell checkpoint blockade.

Opportunity within Immuno-oncology

Immuno-oncology is revolutionizing cancer treatment with the potential of becoming a new standard of care and a 27 billion USD industry already by 20211.

FDA approved  antibodies against immune checkpoint pathways, such as PD-L1/PD-1 (Approved 2014) and CTLA-4 (Approved 2011) and the clinical effects are unprecedented for several cancer forms. The Nobel Prize in Medicine 2018 was awarded for the discovery of PD1 and CTLA-4. However, the response rates are currently 20-30%, and several common cancer forms remain close to unresponsive. One reason is that the tumor micro environment has additional different suppressive pathways. A bottleneck for further improvement is to identify new pharmacological targets in addition to the PD-L1/PD-1 and CTLA-4 axis.

About

Genagon Therapeutics was founded in 2015 and is rapidly growing a strong and broad patent portfolio with many projects and opportunities for internal development or partnerships. The company is supported financially by among others, Beijer Ventures and Almi Invest

Team

Simon Fredriksson, Ph.D 

Founder and CEO – Experienced life science entrepreneur. Co-founder and former CSO and CEO of Olink AB. Research at Uppsala and Stanford Universities has resulting in multiple high impact papers in Nature Biotech, PNAS, Nature Methods. 10 patents have been commercialized into products at Olink, Agilent, and ThermoFisher, especially the Proximity Ligation and Proximity Extension assays for multiplex protein detection. Previously Board member of Olink AB (9 years), Biolamina AB (6 years). Presently Board member of Cartana AB and Olink Proteomics AB.

Andries Blokzijl, MD Ph.D

Founder and CSO – Licensed physician and researcher in signal transduction. Developed Genagon’s in-house immune cell signaling decoding process. Highly cited publications in journals such as Nature Methods, Molecular and Cellular Proteomics, Genes & Dev, J Cell Biol.

Moa Fransson, Ph.D

COO –  PhD in Gene and Immunotherapy and has since graduating worked in a variety of institutions dealing with project management and innovation. Awarded numerous scholarship for doctoral and postdoctoral research and previous trained at the Business Lab at the Uppsala Innovation Center and is a co-founder of BioFlow systems AB.

Evelina Lindmark, Ph.D

Senior scientist – PhD in Translational Immunology from Karolinska Institute specializing in antigen presenting cells in autoimmunity. Previous industrial experience as QA/QC scientist and project manager at 3H Biomedical in Uppsala.

Katrin Klocke, Ph.D

Senior scientist – PhD in immunology from Karolinska Institute specializing in CTLA-4 within autoimmune diseases and in vivo models. Previous experience from Rheinische Friedrich-Wilhelms-Universität Bonn in Germany.

Cecilia Drakskog, Msc, BMA

Scientist and Laboratory Manager – Immununologist and infection biologist with experience in assay development from Stockholm University and Karolinska Institute with a broad background in laboratory management.

Anders Nordström, Chairman

Mr. Nordström has a long and versatile professional experience from executive positions in Life Science companies such as CFO, Executive Vice President and as a Board Member in global life science companies and Startup companies e.g. Halo Genomics. He has held executive positions in Phadia, Pharmacia as well as in ArthroCare International including international assignments in the US and Canada. He is currently working as Senior Advisor, Business Development at Uppsala Innovation Centre and has served as Chairman of the Board in several companies e.g. OssDsign, Vanadis Diagnostics, ExScale Biospecimen Solutions.  Mr. Nordström has a BSc in Business Administration and Economics from University of Uppsala, Sweden.

Ola Winqvist, MD Ph.D

Ola is a Professor of Cellular Immunotherapy, Head of Translational Immunology, and Senior Consultant in Clinical Immunology at the Karolinska Institutet and Karolinska University Hospital. The Swedish Research Council and the Swedish Cancer Society have continuously supported Ola’s research since 1999, and he has received various competitive grants from the European Union and Swedish Governmental Agency for Innovation Systems for the development of immunological therapeutics. Ola has an M.D and Ph.D. from Uppsala University in Sweden, and did his postdoctoral research at the Scripps Research Institute in the United States.

Svein Mathisen

M.Sc. in engineering physics from the Norwegian University of Science and Technology. More than 25 years of experience in various senior positions in the Norsk Hydro Group and as CEO of BioInvent International AB. Chairman of the Boards of iCell Science AB and Gabather AB. Board member of Athera Biotechnologies AB and Arild Capital AB.

Previous appointments (last five years): Board member and CEO of BioInvent International AB, Chairman of the Board of Biotec Pharmacon ASA and Board member of the industry organization Sweden Bio.

Richard Åhlberg, MD Ph.D 

PhD in immunology, is chief physician at Karolinska University Hospital. He is an experienced life science board member. He has vast experience from the pharmaceutical industry with focus on immuno-oncology from his previous positions as Medical Director and Business Director Oncology at Roche AB. For five years he was the Country Manager for Aleris Healthcare Sweden.

Karin von Wachenfeldt, Ph.D

Karin has a strong scientific expertise in pharmaceutical development of large and small molecules. She obtained her Ph. D in 1993 from Dept. of Immunotechnology at Lund University. Karin has over 20 years of experience from the pharmaceutical industry (BioInvent, Ixsys Inc. PharmaciaUpjohn, Active Biotech and AstraZeneca) developing drugs for cancer and Respiratory/Inflammation. Since 2011 she is the CEO and co-founder of Truly Translational Sweden AB.

Sara Mangsbo, Ph.D

Active in the field of immunotherapy for over 10 years, with extensive knowledge of innate as well as adaptive immunity. Sara has extensive experience of pre-clinical models and has worked with immune targeting mAbs as well as immune complexes and Fc receptors for many years. Sara has also held a position at AstraZeneca as Brand Lead in Immuno-oncology. Currently she leads a research group within Uppsala University and is also an active entrepreneur.

Contact

Visiting address

Nanna Svartz Väg 2

S-171 65 Solna, Sweden

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If you would like to get in touch with us, please send an e-mail to info@genagon.com

Genagon Therapeutics AB

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